Can aspirin reduce the risk of miscarriage?

Can aspirin reduce the risk of miscarriage?

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Aspirin does not improve live birth rates in women with prior abortions.

Although there is no strong evidence of its effectiveness, many doctors prescribe low doses of aspirin to women who have suffered a miscarriage and want to become pregnant again.

A study, published in the prestigious journal The Lancet, shows that low-dose aspirin does not significantly improve the live birth rate or reduce abortions in women who have had previous abortions.

The study included women, ages 18 to 40, who were trying to become pregnant and who had had one or more miscarriages of less than 20 weeks in the previous year. The women received 81 mg / day of aspirin and folic acid or a placebo and folic acid every day before conception for up to six menstrual cycles.

Women who managed to get pregnant during that time continued with the aspirin dose until 36 weeks' gestation.

Usually, there were no differences in pregnancy loss rates between the aspirin and placebo groups. The results showed that 58% of the women who took aspirin managed to get pregnant and give birth, compared to 53% of the women who took the placebo. However, a more detailed analysis of the data revealed that women who had had a single recent miscarriage, before 20 weeks gestation, had a higher rate of pregnancy and live births while on aspirin. Possibly, in this group of women, aspirin increased blood flow to the uterus.

Schisterman EF, Silver RM, Lesher LL, Faraggi D, Wactawski-Wende J, Townsend JM, et al. The Lancet (2014). More information.

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